Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

Short-chain fatty acids (SCFAs) derived from the fermentation of carbohydrates by gut
microbiota play a crucial role in regulating host physiology. Among them, acetate …

Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial
hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV …

Pulmonary hypertension (PH) is a progressive cardiovascular disorder in which local
vascular inflammation leads to increased pulmonary vascular remodeling and ultimately to …

Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease
due to the development of right ventricular (RV) failure. At present, no treatments targeted at …

The right ventricle and its stress response is perhaps the most important arbiter of survival in
patients with pulmonary hypertension of many causes. The physiology of the …

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac
fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory …

Right ventricular (RV) function is the predominant determinant of survival in patients with
pulmonary arterial hypertension (PAH). In preclinical models, pharmacological activation of …

The stressed right ventricle (RV) is particularly susceptible to producing and accumulating
reactive oxygen species, leading to extracellular matrix deposition and secretion of …

Therapeutic options for right ventricular (RV) dysfunction and failure are strongly limited.
Right heart failure (RHF) has been mostly addressed in the context of pulmonary arterial …