Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …

New piperazine–chalcone hybrids and related pyrazoline derivatives have been designed
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …

Breast cancer resistance protein (BCRP/ABCG2), an ATP-binding cassette (ABC) efflux
transporter, plays a critical role in multi-drug resistance (MDR) to anti-cancer drugs and drug …

A novel series of bis (furan‐based chalcone) derivatives linked to aliphatic linkers, with the
furan units at the A‐or B‐rings, were synthesized and evaluated as anticancer agents …

Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy
success. Numerous mechanisms are behind the MDR phenomenon wherein the …

Multi-drug resistance (MDR) is a serious challenge in contemporary clinical practice and is
mostly responsible for the failure of cancer medication therapies. Several experimental …

According to Global Cancer Statistics 2021, female breast cancer has exceeded lung cancer
as the most frequently diagnosed cancer. As a result of this widespread breast cancer, it is …