The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

The metastatic potential of cells is an important parameter in the design of optimal strategies
for the personalized treatment of cancer. Using atomic force microscopy (AFM), we show …

Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses and are major sites of information processing …

Directional migration is an important component of cell motility. Although the basic
mechanisms of random cell movement are well characterized, no single model explains the …

Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and
the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

Stress fibers play a central role in adhesion, motility, and morphogenesis of eukaryotic cells,
but the mechanism of how these and other contractile actomyosin structures are generated …

Cofilin and actin-depolymerizing factor (ADF) are actin-binding proteins that play an
essential role in regulating actin filament dynamics and reorganization by stimulating the …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …