Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer

CMC Li, A Cordes, MUJ Oliphant, SA Quinn… - Nature Genetics, 2024 - nature.com
Germline BRCA1 mutation carriers face a high breast cancer risk; however, the underlying
mechanisms for this risk are not completely understood. Using a new genetically engineered …

ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility

M Miyano, MA LaBarge - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer is common among the women in the US, especially in older
women. Genetic mutations and aging are major risk factors. The breast undergoes changes …

The Impact of Urinary Tract Infections, Pregnancy, and Aging on Mammary Tissue Homeostasis

SM Henry - 2024 - search.proquest.com
The majority of breast cancer cases are sporadic, meaning they occur without a known
genetic predisposition or familial inheritance pattern. Various risk factors such as age …