Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the
genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform …

Mutations that directly affect transcription by RNA polymerases rank among the most central
mediators of malignant transformation, but the frequency of new anticancer drugs that …

More than 98% of the human genome is comprised of non-protein coding sequences.
Interestingly, a considerable fraction of these sequences is transcribed into non-protein …

Besides translation, transfer RNAs (tRNAs) play many non-canonical roles in various
biological pathways and exhibit highly variable expression profiles. To unravel the emerging …

Epigenetic control is an important aspect of gene regulation. Despite detailed understanding
of protein-coding gene expression, the transcription of noncoding RNA genes by RNA …

Oncogenically transformed cells overexpress the non-coding RNAs, such as pre-ribosomal
RNA (rRNA) and transfer RNA (tRNA), which are produced by RNA polymerases (Pols) I …

Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were
interspersed in the entire genome. Recent studies suggested that dysregulation was …

The most abundant cellular RNA species, ribosomal RNA (rRNA), appears to be a source of
massive amounts of non-randomly generated fragments. We found rRNA fragments (rRFs) …

Transcription by RNA polymerase III (pol III) is responsible for~ 15% of total cellular
transcription through the generation of small structured RNAs such as tRNA and 5S RNA …

Transfer RNAs (tRNAs) are essential for mRNA translation. They are transcribed in the
nucleus by RNA polymerase III and undergo many modifications before contributing to …