Tumor growth is essentially the result of an evolving cross-talk between malignant and
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …

Vestigial-like family (VGLL) members are mammalian orthologs of vestigial gene in
Drosophila, and they consist of four homologs (VGLL1–4). VGLL members have TDU motifs …

Ovarian cancer is the most lethal gynecological cancer, where survival rates have had
modest improvement over the last 30 years. Metastasis of cancer cells is a major clinical …

Background Loss of heterozygosity (LOH) is a common genetic event in cancer
development, and is known to be involved in the somatic loss of wild-type alleles in many …

Ovarian carcinomas exhibit extensive heterogeneity, and their etiology remains unknown.
Histological and genetic evidence has led to the proposal that low grade ovarian serous …

Epithelial ovarian cancer (EOC) is the leading cause of death in women with gynecological
malignancies. Among EOC, clear cell carcinoma (CCC) and endometrioid adenocarcinoma …

Vestigial-like 3 (VGLL3) is a member of the VGLL family, whose members serve as cofactors
for TEA domain–containing transcription factors (TEADs). TEADs promote tissue and tumor …

The frequent loss of chromosome 17 in epithelial ovarian carcinomas (EOC), particularly
high-grade serous carcinomas (HGSC), has been attributed to the disruption of TP53 (at …

Background Cell line models have proven to be effective tools to investigate a variety of
ovarian cancer features. Due to the limited number of cell lines, particularly of the serous …

Simple Summary Prostate cancer (PCa) is a common male malignancy. FAM107A, or actin-
associated protein, is commonly downregulated in PCa and is associated with a poor patient …