Diagnosis of neonatal sepsis: the past, present and future

IH Celik, M Hanna, FE Canpolat, M Pammi - Pediatric research, 2022 - nature.com
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

Current status of matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry (MALDI-TOF MS) in clinical diagnostic microbiology

S Tsuchida, H Umemura, T Nakayama - Molecules, 2020 - mdpi.com
Mass spectrometry (MS), a core technology for proteomics and metabolomics, is currently
being developed for clinical applications. The identification of microorganisms in clinical …

Diagnosis and treatment of catheter-related bloodstream infection: Clinical guidelines of the Spanish Society of Infectious Diseases and Clinical Microbiology and …

F Chaves, J Garnacho-Montero, JL Del Pozo, E Bouza… - Medicina intensiva, 2018 - Elsevier
Catheter-related bloodstream infections (CRBSI) constitute an important cause of hospital-
acquired infection associated with morbidity, mortality, and cost. The aim of these guidelines …

[HTML][HTML] Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases

J Rello, TSR Van Engelen, E Alp, T Calandra… - Clinical Microbiology …, 2018 - Elsevier
Background Our current understanding of the pathophysiology and management of sepsis is
associated with a lack of progress in clinical trials, which partly reflects insufficient …

Mass spectrometry-based microbiological testing for blood stream infection

F Nomura, S Tsuchida, S Murata, M Satoh… - Clinical Proteomics, 2020 - Springer
Background The most successful application of mass spectrometry (MS) in laboratory
medicine is identification (ID) of microorganisms using matrix-assisted laser desorption …

[HTML][HTML] Impact of MALDI-TOF-MS-based identification directly from positive blood cultures on patient management: a controlled clinical trial

M Osthoff, N Gürtler, S Bassetti, G Balestra… - Clinical Microbiology …, 2017 - Elsevier
Objectives Rapid identification of pathogens directly from positive blood cultures (BC) in
combination with an antimicrobial stewardship programme (ASP) is associated with …

Nano-biotechnology for bacteria identification and potent anti-bacterial properties: a review of current state of the art

S Kaushal, N Priyadarshi, P Garg, NK Singhal, DK Lim - Nanomaterials, 2023 - mdpi.com
Sepsis is a critical disease caused by the abrupt increase of bacteria in human blood, which
subsequently causes a cytokine storm. Early identification of bacteria is critical to treating a …

Proteome analysis of molecular events in oral pathogenesis and virus: a review with a particular focus on periodontitis

S Tsuchida - International Journal of Molecular Sciences, 2020 - mdpi.com
Some systemic diseases are unquestionably related to periodontal health, as periodontal
disease can be an extension or manifestation of the primary disease process. One example …

Comparing the efficacy of MALDI-TOF MS and sequencing-based identification techniques (Sanger and NGS) to monitor the microbial community of irrigation water

BB Surányi, B Zwirzitz, C Mohácsi-Farkas, T Engelhardt… - Microorganisms, 2023 - mdpi.com
In order to intensify and guarantee the agricultural productivity and thereby to be able to feed
the world's rapidly growing population, irrigation has become very important. In parallel, the …

Diagnostic test accuracy of an automated device for the MALDI target preparation for microbial identification

A Cherkaoui, A Riat, G Renzi, A Fischer… - European Journal of …, 2023 - Springer
The objective of this study was to evaluate the performance of the Copan Colibrí™ against
the manual preparation of the MALDI targets. We analyzed 416 (31 different species) non …