Narrative identity in the psychosis spectrum: a systematic review and developmental model
Individuals with schizophrenia-spectrum disorders face profound challenges as they attempt
to maintain identity through the course of illness. Narrative identity—the study of internalized …
to maintain identity through the course of illness. Narrative identity—the study of internalized …
Systematic review of functional MRI applications for psychiatric disease subtyping
L Miranda, R Paul, B Pütz, N Koutsouleris… - Frontiers in …, 2021 - frontiersin.org
Background: Psychiatric disorders have been historically classified using symptom
information alone. Recently, there has been a dramatic increase in research interest not only …
information alone. Recently, there has been a dramatic increase in research interest not only …
Subtyping schizophrenia patients based on patterns of structural brain alterations
Schizophrenia is a complex and heterogeneous syndrome. Whether quantitative imaging
biomarkers can identify discrete subgroups of patients as might be used to foster …
biomarkers can identify discrete subgroups of patients as might be used to foster …
Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance
SC Page, SR Sripathy, F Farinelli… - Proceedings of the …, 2022 - National Acad Sciences
Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …
[HTML][HTML] Neurobiological divergence of the positive and negative schizophrenia subtypes identified on a new factor structure of psychopathology using non-negative …
Background Disentangling psychopathological heterogeneity in schizophrenia is
challenging, and previous results remain inconclusive. We employed advanced machine …
challenging, and previous results remain inconclusive. We employed advanced machine …
Rationale for adjunctive treatment targeting multiple mechanisms in schizophrenia
BJ Kinon, S Leucht, C Tamminga, A Breier… - The Journal of …, 2024 - psychiatrist.com
Importance: Schizophrenia is a complex syndrome with taxing symptoms and for which
treatment challenges remain. Current dopamine D 2 receptor–blocking antipsychotics have …
treatment challenges remain. Current dopamine D 2 receptor–blocking antipsychotics have …
Improving individual predictions: machine learning approaches for detecting and attacking heterogeneity in schizophrenia (and other psychiatric diseases)
HG Schnack - Schizophrenia research, 2019 - Elsevier
Psychiatric diseases are very heterogeneous both in clinical manifestation and etiology.
With the recent rise of using machine learning techniques to attempt to diagnose and …
With the recent rise of using machine learning techniques to attempt to diagnose and …
An investigation of psychosis subgroups with prognostic validation and exploration of genetic underpinnings: the PsyCourse study
Importance Identifying psychosis subgroups could improve clinical and research precision.
Research has focused on symptom subgroups, but there is a need to consider a broader …
Research has focused on symptom subgroups, but there is a need to consider a broader …
Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning
Psychiatric disorders show heterogeneous symptoms and trajectories, with current nosology
not accurately reflecting their molecular etiology and the variability and symptomatic overlap …
not accurately reflecting their molecular etiology and the variability and symptomatic overlap …
Schizophrenia is associated with altered DNA methylation variance
Varying combinations of genetic and environmental risk factors are thought to underpin
phenotypic heterogeneity between individuals in psychiatric conditions such as …
phenotypic heterogeneity between individuals in psychiatric conditions such as …