ER stress and the unfolded protein response in neurodegeneration
The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …
alteration in the functionality of distinct neuronal populations. The pathology of many …
The contribution of the peripheral immune system to neurodegeneration
F Berriat, CS Lobsiger, S Boillée - Nature Neuroscience, 2023 - nature.com
Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …
react to neurodegeneration, but other immune cell types are also able to react to pathology …
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
M Wang, RJ Kaufman - Nature, 2016 - nature.com
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein …
proteins that enter the secretory pathway. Environmental insults or increased protein …
[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal
R Kandimalla, V Thirumala, PH Reddy - Biochimica et Biophysica Acta …, 2017 - Elsevier
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …
Dynamic m6A modification regulates local translation of mRNA in axons
J Yu, M Chen, H Huang, J Zhu, H Song… - Nucleic acids …, 2018 - academic.oup.com
Abstract N 6-methyladenosine (m6A) is a reversible modification in mRNA and has been
shown to regulate processing, translation and decay of mRNA. However, the roles of m6A …
shown to regulate processing, translation and decay of mRNA. However, the roles of m6A …
Simple, scalable proteomic imaging for high-dimensional profiling of intact systems
Combined measurement of diverse molecular and anatomical traits that span multiple levels
remains a major challenge in biology. Here, we introduce a simple method that enables …
remains a major challenge in biology. Here, we introduce a simple method that enables …
[HTML][HTML] Dynamic axonal translation in developing and mature visual circuits
Local mRNA translation mediates the adaptive responses of axons to extrinsic signals, but
direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an …
direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an …
Insulin resistance and diabetes mellitus in Alzheimer's disease
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …
insulin resistance. The term insulin resistance is very wide and could affect different proteins …
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …
conditions and increased prevalence is of public concern. Recent research has provided …