Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Genome-wide studies have identified thousands of long noncoding RNAs (lncRNAs) lacking
protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in …

The MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) locus is
misregulated in many human cancers and produces an abundant long nuclear-retained …

RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …

Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

Most of the human genome is transcribed, yielding a complex network of transcripts that
includes tens of thousands of long noncoding RNAs. Many of these transcripts have a 5 …

tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …