In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These
variants convergently acquired amino acid substitutions at critical residues in the spike …

Drugs that target the human serotonin 2A receptor (5-HT2AR) are used to treat
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …

Tetraspanins play critical roles in various physiological processes, ranging from cell
adhesion to virus infection. The members of the tetraspanin family have four membrane …

Many drugs target the serotonin 2A receptor (5-HT2AR), including second-generation
antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce …

Owing to the development of brilliant microfocus beamlines, rapid-readout detectors and
sample changers, protein microcrystallography is rapidly becoming a popular technique for …

Peptides that contain β-amino acids display stable secondary structures, such as helices
and sheets, and are often referred to as foldamers. Cyclic β2, 3-amino acids (cβAAs), such …

Photolyases, a ubiquitous class of flavoproteins, use blue light to repair DNA photolesions.
In this work, we determined the structural mechanism of the photolyase-catalyzed repair of a …

The crystal structure of the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl
cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (β2AR-Gs …

Beta adrenergic receptors (βARs) mediate physiologic responses to the catecholamines
epinephrine and norepinephrine released by the sympathetic nervous system. While the …

FtsZ polymerizes into protofilaments to form the Z-ring that acts as a scaffold for accessory
proteins during cell division. Structures of FtsZ have been previously solved, but detailed …