Abstract Background Membrane proteins (MPs) play diverse and important functions in
living organisms. They constitute 20% to 30% of the known bacterial, archaean and …

Achromatopsia (ACHM) is a congenital cone photoreceptor disorder characterized by
impaired color discrimination, low visual acuity, photosensitivity, and nystagmus. To date, six …

Recent structure-based computational studies suggest that, in contrast to the classical
description of equilibrium fluctuations as wigglings and jigglings, proteins have access to …

Recently, protein sequence coevolution analysis has matured into a predictive powerhouse
for protein structure and function. Direct methods, which use global statistical models of …

Achromatopsia is an autosomal recessive cone photoreceptor disease that is frequently
caused by pathogenic variants in the CNGA3 gene. Here, we present a systematic functional …

Purpose CNGA3 encoding the main subunit of the cyclic nucleotide-gated ion channel in
cone photoreceptors is one of the major disease-associated genes for achromatopsia. Most …

Background Achromatopsia (ACHM) is a severe congenital autosomal recessive retinal
disorder caused by loss of cone photoreceptors. Here, we aimed to determine the …

Abstract Guanosine 3′ 5′ cyclic monophosphate (cGMP) is synthesized by soluble
guanylyl cyclase (sGC) when vascular smooth muscle is stimulated with nitric oxide (NO) …

High-risk human papillomaviruses (HPV) infect squamous epithelia and cause
hyperproliferative lesions that can progress to cancer. During infection, the virus interacts …

C one photoreceptor dystrophies are a group of rare eye disorders that cause visual
impairments from early in life. Achromatopsia is an inherited cone dystrophy with visual …