Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …

Dye-binding assays, such as those utilizing Congo red and thioflavin T, are among the most
widely used tools to probe the aggregation of amyloidogenic biomolecules and for the …

Neurodegenerative diseases are still a challenge for effective treatments. The high cost of
approved drugs, severity of side effects, injection site pain, and restrictions on drug delivery …

Alzheimer's disease (AD) is the most widespread form of dementia, affecting about 45
million people worldwide. Although the β-amyloid peptide (Aβ) remains the most …

Abstract β-Amyloid oligomers (AβOs) and neuroinflammation are 2 main culprits to
counteract in Alzheimer's disease (AD). Doxycycline (DOXY) is a second generation …

Combined results of theoretical molecular dynamic simulations and in vitro spectroscopic
(circular dichroism and fluorescence) studies are presented, providing the atomistic and …

Abstract Amyloid peptides, Aβ1–40 and Aβ1–42, represent major molecular targets to
develop potential drugs and diagnostic tools for Alzheimer's Disease (AD). In fact, oligomeric …

The use of tetracyclines has declined because of the appearance of resistant bacterial
strains. However, the indications of nonantimicrobial activities of these drugs have …

The chief and largely terminal element of normal blood clotting is considered to involve the
polymerisation of the mainly α-helical fibrinogen to fibrin, with a binding mechanism …

To identify food and beverages that provide the regular intake of natural compounds
capable of interfering with toxic amyloidogenic aggregates, we developed an experimental …