Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

Influenza virus and coronavirus epidemics or pandemics have occurred in succession
worldwide throughout the early 21st century. These epidemics or pandemics pose a major …

Highlights•Advances in the combination of the CuAAC reaction with direct screening.•Before
library assembly, the bioisosteric potential of 1, 2, 3-triazole should be confirmed.•The …

Introduction As a therapeutic antiviral agent, the clinical application of amantadine (AM) is
limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses …

Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …

The channel-forming activity of a family of small, hydrophobic integral membrane proteins
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …

Influenza A virus is the most virulent influenza subtype and is associated with large-scale
global pandemics characterized by high levels of morbidity and mortality. Developing simple …

The ongoing threat of seasonal and pandemic influenza to human health requires antivirals
that can effectively supplement existing vaccination strategies. The M2 protein of influenza A …

The homotetrameric influenza A M2 channel (AM2) is an acid-activated proton channel
responsible for the acidification of the influenza virus interior, an important step in the viral …

Influenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main
treatment strategies–vaccination and small molecule anti-influenza drugs are currently …