Metabolic syndrome: from the genetics to the pathophysiology

S Sookoian, CJ Pirola - Current hypertension reports, 2011 - Springer
The metabolic syndrome (MS) constitutes a combination of underlying risk factors for an
adverse outcome, cardiovascular disease. Thus, the clinical behavior of the MS can be …

Emotional eating as a mediator between depression and weight gain

T van Strien, H Konttinen, JR Homberg, RCME Engels… - Appetite, 2016 - Elsevier
Depression is often associated with weight gain but underlying mechanisms are unclear.
This study assessed whether three psychological eating styles (emotional eating, external …

DNA methylation in obesity and type 2 diabetes

VDF de Mello, L Pulkkinen, M Lalli… - Annals of …, 2014 - Taylor & Francis
To elucidate the mechanisms related to the development of type 2 diabetes (T2D) and other
degenerative diseases at a molecular level, a better understanding of the changes in the …

Emotional eating in adolescents: A gene (SLC6A4/5-HTT)–Depressive feelings interaction analysis

T van Strien, CS van der Zwaluw… - Journal of psychiatric …, 2010 - Elsevier
Eating in response to distress–ie emotional eating–is highly prevalent in (female) adults with
binge eating, but has only a very low prevalence in young children. The present study …

Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study

J Zhao, J Goldberg, V Vaccarino - International journal of obesity, 2013 - nature.com
Objective: Epigenetic mechanisms are increasingly being recognized as an important factor
for obesity. The serotonin transporter gene (SLC6A4) has a critical role in regulating food …

Peripheral biomarkers of treatment-resistant schizophrenia: Genetic, inflammation and stress perspectives

S Jiao, T Cao, H Cai - Frontiers in Pharmacology, 2022 - frontiersin.org
Treatment-resistant schizophrenia (TRS) often results in severe disability and functional
impairment. Currently, the diagnosis of TRS is largely exclusionary and emphasizes the …

[HTML][HTML] Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance

W Zha, HTB Ho, T Hu, MF Hebert, J Wang - Scientific Reports, 2017 - nature.com
Depression and use of antidepressant medications are both associated with increased risk
of obesity, potentially attributed to a reduced serotonin transporter (SERT) function …

Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity?

R Dalle Molle, H Fatemi, A Dagher, RD Levitan… - Neuroscience & …, 2017 - Elsevier
The differential susceptibility model states that a given genetic variant is associated with an
increased risk of pathology in negative environments but greater than average resilience in …

The serotonin transporter promoter polymorphism (5-HTTLPR) is associated with type 2 diabetes

M Iordanidou, A Tavridou, I Petridis, KI Arvanitidis… - Clinica Chimica …, 2010 - Elsevier
BACKGROUND: The serotonergic system contributes substantially to the regulation of
glucose homeostasis and feeding. 5-HTTLPR is a serotonin transporter (5-HTT) gene-linked …

Testing the null hypothesis: comments on 'Culture-gene coevolution of individualism–collectivism and the serotonin transporter gene'

DTA Eisenberg, MG Hayes - Proceedings of the Royal …, 2011 - royalsocietypublishing.org
Chiao & Blizinsky's [1] recently published study,'Culture-gene coevolution of individualism–
collectivism and the serotonin transporter gene', addressed an important and under-studied …