Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …

Context: Atherosclerosis is a progressive pathological process and a leading cause of
mortality worldwide. Clinical research and epidemiological studies state that atherosclerosis …

Chronic inflammation and persistent oxidative stress contribute to the development and
progression of vascular proliferative diseases. We hypothesized that the proinflammatory …

Aims/hypothesis In diabetes, increased retinal oxidative stress is seen before the
mitochondria are damaged. Phagocyte-like NADPH oxidase-2 (NOX2) is the predominant …

The mechanism underlying the role of oxidative stress and advanced oxidation protein
products (AOPPs) in the aetiology of premature ovarian insufficiency (POI) is poorly …

Oxidized low-density lipoprotein (oxLDL) induces endothelial cell death through the
activation of NF-κB and AP-1 pathways. TRAF3IP2 is a redox-sensitive cytoplasmic adapter …

Atherosclerosis is a multifactorial chronic and inflammatory disease of medium and large
arteries, and the major cause of cardiovascular morbidity and mortality worldwide. The …

Sustained activation of the Renin–Angiotensin–Aldosterone System (RAAS) contributes to
the pathogenesis of heart failure. Aldosterone (Aldo) is known to induce both myocardial …

Background Advanced oxidation protein products (AOPPs) are acknowledged as a novel
marker of oxidation-mediated protein damage. This study aimed to investigate the plasma …

Background Paeoniflorin, a monoterpene glycoside, exerts protective vascular effects,
showing good antioxidant properties. However, whether Paeoniflorin has protective effect …