Direct inhibition of IRF-dependent transcriptional regulatory mechanisms associated with disease
A Antonczyk, B Krist, M Sajek, A Michalska… - Frontiers in …, 2019 - frontiersin.org
Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …
TLRs/NLRs: Shaping the landscape of host immunity
Innate immune system provides the first line of defense against pathogenic organisms. It has
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
G Zhang, B Chan, N Samarina… - Proceedings of the …, 2016 - National Acad Sciences
The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is
mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role …
mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role …
The role of gammaherpesviruses in cancer pathogenesis
Worldwide, one fifth of cancers in the population are associated with viral infections. Among
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
Kaposi's sarcoma-associated herpesvirus terminal repeat regulates inducible lytic gene promoters
Y Izumiya, A Algalil, JM Espera, H Miura… - Journal of …, 2024 - Am Soc Microbiol
The Kaposi's sarcoma-associated herpesvirus (KSHV) genome consists of an approximately
140-kb unique coding region flanked by 30–40 copies of a 0.8-kb terminal repeat (TR) …
140-kb unique coding region flanked by 30–40 copies of a 0.8-kb terminal repeat (TR) …
KSHV: immune modulation and immunotherapy
G Broussard, B Damania - Frontiers in immunology, 2020 - frontiersin.org
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is associated with KS, primary
effusion lymphoma (PEL), and multicentric Castleman disease (MCD). To ensure its own …
effusion lymphoma (PEL), and multicentric Castleman disease (MCD). To ensure its own …
Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?
B Damania, DP Dittmer - Journal of medical virology, 2023 - Wiley Online Library
This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that
manifests under diverse and divergent circumstances. We begin with a historical …
manifests under diverse and divergent circumstances. We begin with a historical …
LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes
During the latent phase, Kaposi's sarcoma-associated herpes virus (KSHV) maintains itself
inside the host by escaping the host immune surveillance mechanism through restricted …
inside the host by escaping the host immune surveillance mechanism through restricted …
T cell immunity in HSV-1-and VZV-infected neural ganglia
Herpesviruses hijack the MHC class I (MHC I) and class II (MHC II) antigen-presentation
pathways to manipulate immune recognition by T cells. First, we illustrate herpes simplex …
pathways to manipulate immune recognition by T cells. First, we illustrate herpes simplex …
Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication
K Brulois, Z Toth, LY Wong, P Feng, SJ Gao… - Journal of …, 2014 - Am Soc Microbiol
The downregulation of immune synapse components such as major histocompatibility
complex class I (MHC-I) and ICAM-1 is a common viral immune evasion strategy that …
complex class I (MHC-I) and ICAM-1 is a common viral immune evasion strategy that …