Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …

The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …

Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

The term “immune privilege” was originally coined to describe the suppression of
inflammatory responses within organs protected by anatomic barriers, ie, the eyes, brain …

Abstract Th17-polarized CD4+ effector T-cells together with their immunosuppressive
regulatory T-cell (Treg) counterparts, with transcriptional profiles governed by the lineage …

Regulatory T cells (Treg) play a key role in maintaining the balance of immune responses in
human health and in disease. Treg come in many flavors and can utilize a variety of …

Expansion of human regulatory T cells (Tregs) for clinical applications offers great promise
for the treatment of undesirable immune responses in autoimmunity, transplantation, allergy …

Many epithelial cancers are associated with chronic inflammation. However, the features of
inflammation that are procarcinogenic are not fully understood. Regulatory T cells (Treg) …

Background The crosstalk between the immune system and cancer cells has aroused
considerable interest over the past decades. To escape immune surveillance cancer cells …