Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy of childhood.
To define the clinical and hematologic characteristics of the disease, we performed a …

Covalent modification of histones on chromatin is a dynamic mechanism by which various
nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented …

We conducted a retrospective analysis of 968 adults with acute myeloid leukemia (AML) on
5 recent Southwest Oncology Group trials to understand how the nature of AML changes …

The major established cause of acute myeloid leukemia (AML) in the young is cancer
chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de …

Severe chronic neutropenia (SCN) is defined as an absolute neutrophil (ANC) of less than
0.5× 109/L, lasting for months or years. Congenital, cyclic, and idiopathic neutropenia are …

R115777 is a nonpeptidomimetic enzyme-specific inhibitor of farnesyl protein transferase
(FT) that was developed as a potential inhibitor of Ras protein signaling, with antitumor …

Loss of chromosome 7 and del (7q)[− 7/del (7q)] are recurring cytogenetic abnormalities in
hematologic malignancies, including acute myeloid leukemia and therapy-related myeloid …

Multi-parameter flow cytometry, molecular genetics, and cytogenetic studies have all
contributed to new classification of leukemia. In this review we discuss immunophenotypic …

Familial cases of myelodysplastic syndromes are rare, but are immensely valuable for the
investigation of the molecular pathogenesis of myelodysplasia in general. The best …

A was less than 4 years, with any type of myelodysplasia and monosomy 7. All other
patients, including older children BOUT 40 YEARS ago two forms of chronic myelocytic …