I. Introduction II. 9S Receptors A. Estrogen receptors (ERs) B. Progesterone receptors (PRs)
C. Androgen receptors (ARs) D. Glucocorticoid receptors (GRs) E. Mineralocorticoid …

Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

To maintain quality control in cells, mechanisms distinguish among improperly folded
peptides, mature and functional proteins, and proteins to be targeted for degradation. The …

Hsp90 is an abundant molecular chaperone essential to the establishment of many cellular
regulation and signal transduction systems, but remains one of the least well described …

Glucocorticoids are small lipophilic compounds that mediate their many biological effects by
binding an intracellular receptor (GR) that, in turn, translocates to the nucleus and directly or …

We present an analysis of over 1,100 of the∼ 10,000 predicted proteins encoded by the
genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of …

We have identified a new first step in the hormonal activation of the glucocorticoid receptor
(GR). Rather than causing immediate dissociation of the cytoplasmic GR heterocomplex …

A cyclophilin‐D affinity matrix was employed to isolate components of the mitochondrial
permeability transition pore. A cDNA encoding cyclophilin‐D was cloned from a rat liver …

The in vivo function of the heat shock protein 90 (Hsp90) molecular chaperone is dependent
on the binding and hydrolysis of ATP, and on interactions with a variety of co‐chaperones …

The activation and/or stability of many of the key regulatory and signalling proteins of the
eukaryotic cell depends on their interaction with the Hsp90 molecular chaperone. Hsp90s …