Polyphenols are believed to possess numerous health benefits and can be grouped as
phenolic acids, flavonoids or non-flavonoids. Research involving the synthesis of …

A large series of different ion channels have been identified and investigated as potential
targets for new medicines for the treatment of a variety of human diseases, including pain …

Neuropathic pain is a major health problem that affects up to 7–10% of the population
worldwide. Currently, neuropathic pain is difficult to treat because of its elusive mechanisms …

Current therapies for the treatment of chronic pain provide inadequate relief for millions of
suffering patients, demonstrating the need for better therapies that will treat pain effectively …

Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are
activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial …

Purinergic signaling has recently been suggested to constitute the cellular mechanism
underlying acupuncture-induced analgesia (AA). By extending the original hypothesis on …

This review summarizes experimental evidence indicating that purinergic mechanisms are
causally involved in acupuncture (AP)-induced analgesia. Electroacupuncture (EAP) and …

The permeability of large cations through the P2X pore has remained arguably the most
controversial and complicated topic in P2X-related research, with the emergence of …

Methylene blue (MB) is a cationic thiazine dye, widely used as a biological stain and
chemical indicator. Growing evidence have revealed that MB functions to restore abnormal …

Voltage-gated calcium channel auxiliary α2δ subunits are important for channel trafficking
and function. Here, we compare the effects of α2δ-1 and an α2δ-like protein called Cachd1 …