Genetic architecture of schizophrenia: a review of major advancements
SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …
technological advancements have led to a substantial increase in knowledge of the genetic …
A systematic review and analysis of the use of polygenic scores in pharmacogenomics
D Johnson, MKAP Wilke, SM Lyle… - Clinical …, 2022 - Wiley Online Library
Polygenic scores (PGSs) have emerged as promising tools for complex trait risk prediction.
The application of these scores to pharmacogenomics provides new opportunities to …
The application of these scores to pharmacogenomics provides new opportunities to …
[HTML][HTML] Grey and white matter microstructure is associated with polygenic risk for schizophrenia
Recent discovery of approximately 270 common genetic variants associated with
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
[HTML][HTML] A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank
Psychiatric disorders are highly heritable and associated with a wide variety of social
adversity and physical health problems. Using genetic liability (rather than phenotypic …
adversity and physical health problems. Using genetic liability (rather than phenotypic …
The effect of polygenic risk scores for major depressive disorder, bipolar disorder and schizophrenia on morphological brain measures: a systematic review of the …
Background Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …
[HTML][HTML] The genetic relationships between brain structure and schizophrenia
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …
structure but it has been unclear which genes are associated with both schizophrenia and …
[HTML][HTML] Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses—a general population study
A strong genetic background for psychoses is well-established. Most individuals with a high
genetic risk for schizophrenia, however, do not develop the disorder. We investigated …
genetic risk for schizophrenia, however, do not develop the disorder. We investigated …
Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects
BackgroundSchizotypy is a putative risk phenotype for psychosis liability, but the overlap of
its genetic architecture with schizophrenia is poorly understood. MethodsWe tested the …
its genetic architecture with schizophrenia is poorly understood. MethodsWe tested the …
Linking polygenic risk of schizophrenia to variation in magnetic resonance imaging brain measures: a comprehensive systematic review
Background and hypothesis Schizophrenia is highly heritable, with a polygenic effect of
many genes conferring risk. Evidence on whether cumulative risk also predicts alterations in …
many genes conferring risk. Evidence on whether cumulative risk also predicts alterations in …
The schizophrenia syndrome, circa 2024: What we know and how that informs its nature
R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
becomes necessary to periodically revisit exactly what we know. Along with a need to review …