Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions

MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …

Base‐controlled selectivity in the synthesis of linear and angular fused quinazolinones by a palladium‐catalyzed carbonylation/nucleophilic aromatic substitution …

J Chen, K Natte, A Spannenberg… - Angewandte Chemie …, 2014 - Wiley Online Library
A new approach for the facile synthesis of fused quinazolinone scaffolds through a
palladium‐catalyzed carbonylative coupling followed by an intramolecular nucleophilic …

Palladium‐Catalyzed Carbonylative Four‐Component Synthesis of Thiochromenones: The Advantages of a Reagent Capsule

C Shen, A Spannenberg, XF Wu - … Chemie International Edition, 2016 - Wiley Online Library
Multicomponent reactions, especially those involving four or even more reagents, have been
a long‐standing challenge because of the issues associated with balancing reactivity …

Palladium-Catalyzed Approach to the Synthesis of S-heterocycles

N Kaur - Catalysis Reviews, 2015 - Taylor & Francis
Heterocyclic compounds containing sulfur atom is an important division of compounds which
play important role in new drug development. The S-heterocycles synthesis and their …

Highly Efficient Four‐Component Synthesis of 4(3H)‐Quinazolinones: Palladium‐Catalyzed Carbonylative Coupling Reactions

L He, H Li, H Neumann, M Beller… - Angewandte Chemie …, 2014 - Wiley Online Library
Given the importance of quinazolinones and carbonylative transformations, a palladium‐
catalyzed four‐component carbonylative coupling system for the synthesis of diverse 4 (3H) …

Palladium-catalyzed regioselective difluoroalkylation and carbonylation of alkynes

Q Wang, YT He, JH Zhao, YF Qiu, L Zheng, JY Hu… - Organic …, 2016 - ACS Publications
A novel, four-component synthetic strategy to synthesize a series of β-difluoroalkyl
unsaturated esters/amides with high regioslectivity is described. This Pd-catalyzed …

Synthesis and structure investigation of novel pyrimidine-2, 4, 6-trione derivatives of highly potential biological activity as anti-diabetic agent

A Barakat, SM Soliman, AM Al-Majid, G Lotfy… - Journal of Molecular …, 2015 - Elsevier
Abstract Synthesis of (±)-1, 3-dimethyl-5-(1-(3-nitrophenyl)-3-oxo-3-phenylpropyl) pyrimidine-
2, 4, 6 (1H, 3H, 5H)-trione (3) is reported. The structure of compound 3 was deduced by …

Recent asymmetric syntheses of tetrahydroisoquinolines using “named” and some other newer methods

AL Zein, G Valluru, PE Georghiou - Studies in Natural Products Chemistry, 2012 - Elsevier
Isoquinoline alkaloids are a large family of natural products which have a broad variety of
biological activities. Among the members of this class of compounds …

Preparation of Substituted Tetrahydroisoquinolines by Pd(II)-Catalyzed NH2-Directed Insertion of Michael Acceptors into C–H Bonds Followed by NH2-Conjugated …

A Mancinelli, C Alamillo, J Albert, X Ariza… - …, 2017 - ACS Publications
3, 3-Disubstituted tetrahydroisoquinolines are prepared in one step from Michael acceptors
and 2-phenylethylamines under Pd catalysis and Ag2CO3 as an oxidant. Presumably …

A Novel Domino Synthesis of Quinazolinediones by Palladium‐Catalyzed Double Carbonylation

H Li, W Li, A Spannenberg, W Baumann… - … A European Journal, 2014 - Wiley Online Library
Combining commercially available bromoanilines and bromobenzonitriles in a novel double
carbonylation process allows for a straightforward synthesis of isoindolo [1, 2‐b] quinazoline …