Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases

Y Wan, J Xia, J Xu, L Chen, Y Yang, JJ Wu… - Pharmacological …, 2022 - Elsevier
Obesity, is an increasingly global public health problem associated complications. However,
the proven anti-obesity agents are inefficient with adverse side effects; hence attention is …

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

BR Sharma, LNS Gautam, D Adhikari… - Phytotherapy …, 2017 - Wiley Online Library
Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout
the Asian continent, and its medicinal values have been described in Ayurvedic and …

Plumula Nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety

S Chen, X Li, J Wu, J Li, M Xiao, Y Yang, Z Liu… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Plumula Nelumbinis, the green embryo of the
mature seeds of Nelumbo nucifera Gaertn, has a medical history of over 400 years. It is …

Nuciferine-loaded chitosan hydrogel-integrated 3D-printed polylactic acid scaffolds for bone tissue engineering: A combinatorial approach

R Bharathi, G Harini, A Sankaranarayanan… - International Journal of …, 2023 - Elsevier
Critical-sized bone defects resulting from severe trauma and open fractures cannot
spontaneously heal and require surgical intervention. Limitations of traditional bone grafting …

Aporphines: A privileged scaffold in CNS drug discovery

R Zhu, G Jiang, W Tang, X Zhao, F Chen… - European Journal of …, 2023 - Elsevier
Aporphine alkaloids embedded in 4 H-dibenzo [de, g] quinoline four-ring structures belong
to one of the largest subclasses of isoquinoline alkaloids. Aporphine is a privileged scaffold …

Alkaloids from lotus (Nelumbo nucifera): recent advances in biosynthesis, pharmacokinetics, bioactivity, safety, and industrial applications

Z Wang, Y Li, D Ma, M Zeng, Z Wang, F Qin… - Critical Reviews in …, 2023 - Taylor & Francis
Different parts of lotus (Nelumbo nucifera Gaertn.) including the seeds, rhizomes, leaves,
and flowers, are used for medicinal purposes with health promoting and illness preventing …

Impediment of cancer by dietary plant-derived alkaloids through oxidative stress: implications of PI3K/AKT pathway in apoptosis, autophagy, and ferroptosis

P Manogaran, NM Beeraka, RS Paulraj… - Current Topics in …, 2023 - ingentaconnect.com
The adverse toxicities and stemness are two major factors that constrained the usage of
therapeutic strategies to target several cancer types. Previous studies explored the efficacy …

A novel G protein-biased and subtype-selective agonist for a G protein-coupled receptor discovered from screening herbal extracts

B Zhang, S Zhao, D Yang, Y Wu, Y Xin, H Cao… - ACS central …, 2020 - ACS Publications
Subtype selectivity and functional bias are vital in current drug discovery for G protein-
coupled receptors (GPCRs) as selective and biased ligands are expected to yield drug …

Nuciferine inhibits oral squamous cell carcinoma partially through suppressing the STAT3 signaling pathway

JR Xie, XJ Chen, G Zhou - International Journal of Molecular Sciences, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) poses a significant obstacle to the worldwide
healthcare system. Discovering efficient and non-toxic medications is crucial for managing …

Chemistry and biology of nuciferine

X Huang, N Hao, G Chen, S Liu, Z Che - Industrial Crops and Products, 2022 - Elsevier
Nuciferine is an aporphine alkaloid first isolated from Nelumbo nucifera Gaertn as the main
bioactive ingredient. Additionally, it was also obtained from some other plants. Nuciferine …