Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

With the continuous development of immunotherapy, researchers have paid more attention
to the specific immune regulatory mechanisms of various immune responses in different …

An immunosuppressive tumour microenvironment is a major obstacle in the control of
pancreatic and other solid cancers,–. Agonists of the stimulator of interferon g enes (STING) …

Type I interferon (IFN) response is commonly recognized as the main signaling activity of
STING. Here, we generate the Sting1 S365A/S365A mutant mouse that precisely ablates …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Silica is utilized extensively in industrial and commercial applications as a chemical raw
material, increasing its exposure and hazardous potential to populations, with silicosis …

Chronic mucosal pathogens have evolved multiple strategies to manipulate the host
immune response; consequently, microbes contribute to the development of> 2 million …

Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely
probe the local environment and maintain host integrity. Besides pathogen recognition …

Stress is well known to contribute to the development of both neurological and psychiatric
diseases. In the central nervous system, a role for STING (stimulator of interferon genes) in …

Acute pancreatitis (AP) is one of the most common inflammatory diseases of the
gastrointestinal tract and a steady rising diagnosis for inpatient hospitalization. About one in …