Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Circular RNAs in diabetes mellitus and its complications
W Fan, H Pang, Z Xie, G Huang, Z Zhou - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetes mellitus (DM) is an endocrine disorder characterized by a relative or absolute lack
of insulin due to the dysfunction or destruction of β-cells. DM is one of the fastest growing …
of insulin due to the dysfunction or destruction of β-cells. DM is one of the fastest growing …
Acquisition of dynamic function in human stem cell-derived β cells
Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …
[HTML][HTML] Combined inhibition of DYRK1A, SMAD, and trithorax pathways synergizes to induce robust replication in adult human beta cells
P Wang, E Karakose, H Liu, E Swartz, C Ackeifi… - Cell metabolism, 2019 - cell.com
Small-molecule inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) induce
human beta cells to proliferate, generating a labeling index of 1.5%–3%. Here, we …
human beta cells to proliferate, generating a labeling index of 1.5%–3%. Here, we …
DYRK1A inhibitors as potential therapeutics for β-cell regeneration for diabetes
K Kumar, C Suebsuwong, P Wang… - Journal of Medicinal …, 2021 - ACS Publications
According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …
β-cell fate in human insulin resistance and type 2 diabetes: a perspective on islet plasticity
T Mezza, F Cinti, CMA Cefalo, A Pontecorvi… - Diabetes, 2019 - Am Diabetes Assoc
Although it is well established that type 2 diabetes (T2D) is generally due to the progressive
loss of β-cell insulin secretion against a background of insulin resistance, the actual …
loss of β-cell insulin secretion against a background of insulin resistance, the actual …
[HTML][HTML] Type 1 diabetes and engineering enhanced islet transplantation
The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
Modelling the endocrine pancreas in health and disease
Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
Breast milk-derived extracellular vesicles enriched in exosomes from mothers with type 1 diabetes contain aberrant levels of microRNAs
The breast milk plays a crucial role in shaping the initial intestinal microbiota and mucosal
immunity of the infant. Interestingly, breastfeeding has proven to be protective against the …
immunity of the infant. Interestingly, breastfeeding has proven to be protective against the …
Role of TGF-beta signaling in beta cell proliferation and function in diabetes
HL Wang, L Wang, CY Zhao, HY Lan - Biomolecules, 2022 - mdpi.com
Beta (β) cell dysfunction or loss is the common pathological feature in all types of diabetes
mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of …
mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of …