Recent advances and current limitations of available technology to optically manipulate and observe cardiac electrophysiology

GA Marchal, V Biasci, P Yan, C Palandri… - … -European Journal of …, 2023 - Springer
Optogenetics, utilising light-reactive proteins to manipulate tissue activity, are a relatively
novel approach in the field of cardiac electrophysiology. We here provide an overview of …

Optoelectronic control of cardiac rhythm: Toward shock‐free ambulatory cardioversion of atrial fibrillation

V Portero, S Deng, GJJ Boink, GQ Zhang… - Journal of Internal …, 2024 - Wiley Online Library
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, progressive in nature, and
known to have a negative impact on mortality, morbidity, and quality of life. Patients requiring …

Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range

C Ronchi, C Galli, G Tullii, C Marzuoli… - Advanced …, 2024 - Wiley Online Library
Optical stimulation in the red/near infrared range recently gained increasing interest, as a
not‐invasive tool to control cardiac cell activity and repair in disease conditions. Translation …

Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review

O Baines, R Sha, M Kalla, AP Holmes, IR Efimov… - Europace, 2024 - academic.oup.com
State-of-the-art innovations in optical cardiac electrophysiology are significantly enhancing
cardiac research. A potential leap into patient care is now on the horizon. Optical mapping …

Monitoring and modulating cardiac bioelectricity: from Einthoven to End-user

T De Coster, A Nobacht, T Oostendorp, AAF de Vries… - Europace, 2024 - academic.oup.com
In 2024, we celebrate the 100th anniversary of Willem Einthoven receiving the Nobel Prize
for his discovery of the mechanism of the electrocardiogram. Building on Einthoven's legacy …

Reordering and synchronization of electrical turbulence in cardiac tissue through global and partial optogenetical illumination

TC Li, W Zhong, B Ai, WJ Zhu, BW Li, AV Panfilov… - Physical Review E, 2023 - APS
Electrical turbulence in the heart is considered the culprit of cardiac disease, including the
fatal ventricular fibrillation. Optogenetics is an emerging technology that has the capability to …

The promise of optogenetic arrhythmia termination.

T Bruegmann, L Sacconi - Journal of Internal Medicine, 2023 - search.ebscohost.com
Light transmittance in human atrial tissue and transthoracic illumination in rats support
translatability of optogenetic cardioversion of atrial fibrillation. This is further supported by …

Optogenetic modulation of cardiac autonomic nervous system

RA Hernández-Domínguez, JF Herrera-Orozco… - Autonomic …, 2024 - Elsevier
The following is a narrative review of the fundamentals of optogenetics. It focuses on the
advantages and constraints of manipulating the autonomic nervous system by modifying the …

[PDF][PDF] Zhang, GQ, Vries,. de, & Pi nappels, D..(2023)

V Portero, SL Deng, G Boink - … control of cardiac rh … - scholarlypublications …
Portero V, Deng S, Boink GJJ, Zhang GQ, de Vries A, Pijnappels DA. Optoelectronic control
of cardiac rhythm: Toward shock-free ambulatory cardioversion of atrial fibrillation. J Intern …