[HTML][HTML] Regulation of body temperature by the nervous system
The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …
system. Here we review our current understanding of thermoregulation in mammals. We …
Physiological and behavioral mechanisms of thermoregulation in mammals
Simple Summary The study of the hypothalamic neuromodulation of thermoregulation offers
broad areas of opportunity with practical applications that are currently being strengthened …
broad areas of opportunity with practical applications that are currently being strengthened …
The thermoregulation system and how it works
AA Romanovsky - Handbook of clinical neurology, 2018 - Elsevier
Heat exchange processes between the body and the environment are introduced. The
definition of the thermoneutral zone as the ambient temperature range within which body …
definition of the thermoneutral zone as the ambient temperature range within which body …
Neural mechanisms of inflammation-induced fever
A Blomqvist, D Engblom - The Neuroscientist, 2018 - journals.sagepub.com
Fever is a common symptom of infectious and inflammatory disease. It is well-established
that prostaglandin E2 is the final mediator of fever, which by binding to its EP3 receptor …
that prostaglandin E2 is the final mediator of fever, which by binding to its EP3 receptor …
Fever and hypothermia in systemic inflammation
Systemic inflammation-associated syndromes (eg, sepsis and septic shock) often have high
mortality and remain a challenge in emergency medicine. Systemic inflammation is usually …
mortality and remain a challenge in emergency medicine. Systemic inflammation is usually …
Stress-induced hyperthermia and hypothermia
T Oka - Handbook of clinical neurology, 2018 - Elsevier
Stress affects core body temperature (T c). Many kinds of stress induce transient,
monophasic hyperthermia, which diminishes gradually if the stressor is terminated. Stronger …
monophasic hyperthermia, which diminishes gradually if the stressor is terminated. Stronger …
TRPV 1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and …
Aim Thermoregulatory side effects hinder the development of transient receptor potential
vanilloid‐1 (TRPV 1) antagonists as new painkillers. While many antagonists cause …
vanilloid‐1 (TRPV 1) antagonists as new painkillers. While many antagonists cause …
Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat
EPS da Conceição, SF Morrison, G Cano… - Scientific reports, 2020 - nature.com
Within the central neural circuitry for thermoregulation, the balance between excitatory and
inhibitory inputs to the dorsomedial hypothalamus (DMH) determines the level of activation …
inhibitory inputs to the dorsomedial hypothalamus (DMH) determines the level of activation …
Exploration of TRPM8 binding sites by β-carboline-based antagonists and their in vitro characterization and in vivo analgesic activities
A Bertamino, C Ostacolo, A Medina… - Journal of Medicinal …, 2020 - ACS Publications
Transient receptor potential melastatin 8 (TRPM8) ion channel represents a valuable
pharmacological option for several therapeutic areas. Here, a series of conformationally …
pharmacological option for several therapeutic areas. Here, a series of conformationally …
Neurons in the rat ventral lateral preoptic area are essential for the warm‐evoked inhibition of brown adipose tissue and shivering thermogenesis
Aim To determine the role of neurons in the ventral part of the lateral preoptic area (vLPO) in
CNS thermoregulation. Methods In vivo electrophysiological and neuropharmacological …
CNS thermoregulation. Methods In vivo electrophysiological and neuropharmacological …