ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the
integrated stress response. The integrated stress response is triggered by phosphorylation …

Rapid increase in aging populations is an urgent problem because older adults are more
likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare …

Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD):
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …

Maternal infection and inflammation during pregnancy are associated with
neurodevelopmental disorders in offspring, but little is understood about the molecular …

Microglia phenotypes are highly regulated by the brain environment, but the transcriptional
networks that specify the maturation of human microglia are poorly understood. Here, we …

Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …

Background: Cellular redox control is maintained by generation of reactive oxygen/nitrogen
species balanced by activation of antioxidative pathways. Disruption of redox balance leads …

Ischemia-reperfusion injury (IRI), critically involved in the pathology of reperfusion therapy
for myocardial infarction, is closely related to oxidative stress the inflammatory response …

Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …

To maintain proteostasis, cells must integrate information and activities that supervise
protein synthesis, protein folding, conformational stability, and also protein degradation …