Historically, the mammalian brain was thought to lack stem cells as no new neurons were
found to be made in adulthood. That dogma changed∼ 25 years ago with the identification …

The bHLH proteins are a family of eukaryotic transcription factors regulating expression of a
wide range of genes involved in cell differentiation and development. They contain the Helix …

How multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain
development is largely unknown. Here, to systematically map the regulatory landscape of …

During tissue development, multipotent progenitors differentiate into specific cell types in
characteristic spatial and temporal patterns. We addressed the mechanism linking …

Phosphoserine (pSer) sites are primarily located within disordered protein regions, making it
difficult to experimentally ascertain their effects on protein structure and function. Therefore …

Posttranslational modification of proteins by the addition of ubiquitin and related modifiers
has an essential role in cellular processes such as protein degradation and subcellular …

During protein synthesis genetic instructions are passed from DNA via mRNA to the
ribosome to assemble a protein chain. Occasionally, stop codons in the mRNA are …

Abstract Background Basic Helix Loop Helix (bHLH) proneural transcription factors are
master regulators of neurogenesis that act at multiple stages in this process. We have …

Intrinsically-disordered proteins (IDPs) present a complex interplay of conformational
variability and multifunctionality, modulated by environment and post-translational …

Post-translational modifications (PTMs) are key molecular events that modify proteins after
their synthesis and modulate their ultimate functional properties by affecting their stability …