Zebrafish cancer avatars: A translational platform for analyzing tumor heterogeneity and predicting patient outcomes

MA Al-Hamaly, LT Turner, A Rivera-Martinez… - International Journal of …, 2023 - mdpi.com
The increasing number of available anti-cancer drugs presents a challenge for oncologists,
who must choose the most effective treatment for the patient. Precision cancer medicine …

PDX models for functional precision oncology and discovery science

Z Blanchard, EA Brown, A Ghazaryan… - Nature Reviews Cancer, 2024 - nature.com
Precision oncology relies on detailed molecular analysis of how diverse tumours respond to
various therapies, with the aim to optimize treatment outcomes for individual patients. Patient …

Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients with colorectal cancer

B Costa, MF Estrada, A Gomes, LM Fernandez… - Nature …, 2024 - nature.com
Cancer patients often undergo rounds of trial-and-error to find the most effective treatment
because there is no test in the clinical practice for predicting therapy response. Here, we …

Relapsed Ovarian Cancer patients with ascites and/or pleural effusion still benefit from treatment: A real-life study

M Rebordão-Pires, MF Estrada, A Gomes, F Silva… - Cancers, 2023 - mdpi.com
Simple Summary The majority of high grade serous ovarian carcinoma (HGSOC) patients
present with advanced disease, which will relapse and require additional treatment …

Zebrafish Xenographs in Oncology and Personalized Medicine

NA Lunina, DR Safina, SV Kostrov - Molecular Biology, 2024 - Springer
The bony fish Danio rerio (zebrafish) has become one of the important vertebrate model
organisms in biomedical cancer research and is used, among other things, for the …

结直肠癌PDX 模型成瘤率的影响因素及临床意义

张燕萍, 姚刘旭, 丁倩男, 黄则勇… - 基础医学与 …, 2023 - journal11.magtechjournal.com
目的建立结直肠癌(CRC) 患者来源的肿瘤组织异种移植(PDX) 模型, 评估PDX
模型成瘤率的影响因素, 并初步进行化学治疗实验. 方法选取2019 年11 月至2020 年10 …

Répression Polycomb et modèle poisson zèbre en cancérologie

L Raby - 2023 - theses.hal.science
La répression Polycomb exerce une régulation transcriptionnelle par deux complexes
protéiques distincts, les complexes PRC1 et PRC2. Ce contrôle épigénétique est médié par …

Influencing factors and the clinical significance of tumorigenesis rate in PDX model of colorectal cancer

Y ZHANG, L YAO, Q DING… - Basic & Clinical …, 2023 - journal11.magtechjournal.com
Objective To establish a patient derived xenograft (PDX) model of tumor tissue from patients
with colorectal cancer (CRC) and to identify the factors affecting the tumorigenesis rate of …