Mitochondria control various processes that are integral to cellular and organismal
homeostasis, including Ca 2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not …

Legionella pneumophila is a Gram-negative bacterium and the causative agent of
Legionnaires' disease. It replicates within amoeba and infects accidentally human …

Mitochondria are essential and highly dynamic organelles, constantly undergoing fusion
and fission. We analyzed mitochondrial dynamics during infection with the human bacterial …

Microsporidia are strict obligate intracellular parasites that infect a wide range of eukaryotes
including humans and economically important fish and insects. Surviving and flourishing …

Autophagy is a fast-moving field with an enormous impact on human health and disease.
Understanding the complexity of the mechanism and regulation of this process often benefits …

5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and
pathological conditions. AMPK is involved in energy metabolism, which is perturbed by …

The use of simple hosts such as Dictyostelium discoideum in the study of host pathogen
interactions offers a number of advantages and has steadily increased in recent years …

Dictyostelium discoideum offers unique advantages for studying fundamental cellular
processes, host–pathogen interactions as well as the molecular causes of human diseases …

Any established or aspiring model organism must justify itself using two criteria: does the
model organism offer experimental advantages not offered by competing systems? And will …

Dictyostelium discoideum is a haploid social soil amoeba that is an established host model
for several human pathogens. The research areas presently pursued include the use of D …