The development of depression may involve a complex interplay of environmental and
genetic risk factors. PubMed and PsycInfo databases were searched from inception through …

Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …

The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

Stress has pronounced effects on the brain, and thus behavioral outputs. This is particularly
true when the stress occurs during vulnerable points in development. A review of the clinical …

Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could
be associated with the pathophysiology of depression. This study investigated the markers …

The aim of research studies in the field of psychiatry conducted in recent years is to
formulate a consistent theory that would exhaustively explain the aetiology of depression. So …

This study aimed to evaluate the effects of environmental enrichment (EE) in Wistar rats
subjected to maternal deprivation (MD). MD was performed in the first post-natal days (PND) …

Exposures to stress at all stages of development can lead to long-term behavioural effects,
in part through changes in the epigenome. This review describes rodent research …

Major depressive disorder (MDD) is one of the disorders that most causes disability and
affects about 265 million people worldwide, according to the World Health Organization …

This study used an animal model of depression induced by maternal care deprivation (MCD)
to investigate whether depressive behaviour, neuroinflammation and oxidative stress were …