The hypothalamus-pituitary-gonad axis: tales of mice and men

A Kaprara, IT Huhtaniemi - Metabolism, 2018 - Elsevier
Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

Regulation of fish gonadotropins

Z Yaron, G Gur, P Melamed, H Rosenfeld… - International review of …, 2003 - Elsevier
Neurohormones similar to those of mammals are carried in fish by hypothalamic nerve fibers
to regulate directly follicle-stimulating hormone (FSH) and luteinizing hormone (LH) …

Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor

Z Naor - Frontiers in neuroendocrinology, 2009 - Elsevier
Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH
analogs are extensively used in in vitro fertilization, and treatment of sex hormone …

Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells

K Hisamoto, M Ohmichi, H Kurachi, J Hayakawa… - Journal of Biological …, 2001 - ASBMB
Although estrogen is known to activate endothelial nitric oxide synthase (eNOS) in the
vascular endothelium, the molecular mechanism responsible for this effect remains to be …

Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans

CK Cheng, PCK Leung - Endocrine reviews, 2005 - academic.oup.com
In human beings, two forms of GnRH, termed GnRH-I and GnRH-II, encoded by separate
genes have been identified. Although these hormones share comparable cDNA and …

GnRH receptors in cancer: from cell biology to novel targeted therapeutic strategies

P Limonta, MM Marelli, S Mai, M Motta… - Endocrine …, 2012 - academic.oup.com
The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive
functions is well established. These receptors are the target of GnRH agonists (through …

Hormones in synergy: regulation of the pituitary gonadotropin genes

VG Thackray, PL Mellon, D Coss - Molecular and cellular endocrinology, 2010 - Elsevier
The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor

S Kraus, Z Naor, R Seger - Archives of medical research, 2001 - Elsevier
The hypothalamic gonadotropin-releasing hormone (GnRH) is a key regulator of the
reproductive system, triggering the synthesis and release of LH and FSH in the pituitary …

Regulation of gonadotropin subunit gene transcription

LL Burger, DJ Haisenleder, AC Dalkin… - Journal of molecular …, 2004 - jme.bioscientifica.com
Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing
hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the …

Molecular mechanisms of gonadotropin-releasing hormone signaling: integrating cyclic nucleotides into the network

RM Perrett, CA McArdle - Frontiers in endocrinology, 2013 - frontiersin.org
Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian
reproductive function in both males and females. It acts via G-protein coupled receptors on …