Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Complement component C3–The “Swiss Army Knife” of innate immunity and host defense

D Ricklin, ES Reis, DC Mastellos, P Gros… - Immunological …, 2016 - Wiley Online Library
As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

Complement and coagulation: strangers or partners in crime?

MM Markiewski, B Nilsson, KN Ekdahl, TE Mollnes… - Trends in …, 2007 - cell.com
The convergence between complement and the clotting system extends far beyond the
chemical nature of the complement and coagulation components, both of which form …

Structures of complement component C3 provide insights into the function and evolution of immunity

BJC Janssen, EG Huizinga, HCA Raaijmakers, A Roos… - Nature, 2005 - nature.com
The mammalian complement system is a phylogenetically ancient cascade system that has
a major role in innate and adaptive immunity. Activation of component C3 (1,641 residues) is …

Acute motor axonal neuropathy: an antibody‐mediated attack on axolemma

C Hafer‐Macko, ST Hsieh, TW Ho… - Annals of Neurology …, 1996 - Wiley Online Library
The acute motor axonal neuropathy (AMAN) form of the Guillain‐Barré syndrome is a
paralytic disorder of abrupt onset characterized pathologically by motor nerve fiber …

Immune attack on the Schwann cell surface in acute inflammatory demyelinating polyneuropathy

CE Hafer‐Macko, KA Sheikh, CY Li… - Annals of Neurology …, 1996 - Wiley Online Library
The localization, mode of action, and roles of complement in the Guillain‐Barré syndrome
have been controversial. We used high‐resolution immunocytochemistry to localize …

Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis

P Avirutnan, P Malasit, B Seliger, S Bhakdi… - The Journal of …, 1998 - journals.aai.org
Dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) are severe
complications of secondary dengue virus (DV) infection. Vascular leakage, hemorrhagic …

[图书][B] Rossi's principles of transfusion medicine

TL Simon, J McCullough, EL Snyder, BG Solheim… - 2022 - Wiley Online Library
Title: Rossi's principles of transfusion medicine/edited by Toby L. Simon, Eric A. Gehrie,
Jeffrey McCullough, John D. Roback, Edward L. Snyder. Other titles: Principles of …

Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies

KN Ekdahl, JD Lambris, H Elwing, D Ricklin… - Advanced drug delivery …, 2011 - Elsevier
When an artificial biomaterial (eg, a stent or implantable pump) is exposed to blood, plasma
proteins immediately adhere to the surface, creating a new interface between the …

Complement activation in amyloid plaques in Alzheimer's dementia

P Eikelenboom, CE Hack, JM Rozemuller, FC Stam - Virchows Archiv B, 1988 - Springer
Amyloid plaques in Alzheimer's dementia contain complement factors C1q, C4 and C3. In
the present study we demonstrate complement activation in amyloid plaques using …