Virus-like particle vaccines against respiratory viruses and protozoan parasites

KB Chu, FS Quan - 2021 - Springer
The field of vaccinology underwent massive advances over the past decades with the
introduction of virus-like particles (VLPs), a supra-molecular nanoparticle vaccine platform …

Targeting the Plasmodium falciparum proteome and organelles for potential antimalarial drug candidates

J Abugri, J Ayariga, SS Sunwiale, CA Wezena… - Heliyon, 2022 - cell.com
There is an unmet need to unearth alternative treatment options for malaria, wherein this
quest is more pressing in recent times due to high morbidity and mortality data arising mostly …

Mucosal Administration of Recombinant Baculovirus Displaying Toxoplasma gondii ROP4 Confers Protection Against T. gondii Challenge Infection in Mice

KW Yoon, KB Chu, HJ Kang, MJ Kim… - Frontiers in Cellular …, 2021 - frontiersin.org
Pathogens require physical contact with the mucosal surface of the host organism to initiate
infection and as such, vaccines eliciting both mucosal and systemic immune responses …

Recombinant Vaccinia Virus Expressing Plasmodium berghei Apical Membrane Antigen 1 or Microneme Protein Enhances Protection against P. berghei Infection in …

MJ Kim, KB Chu, SH Lee, HJ Kang, KW Yoon… - Tropical Medicine and …, 2022 - mdpi.com
Recombinant vaccinia viruses (rVV) are effective antigen delivery vectors and are
researched widely as vaccine platforms against numerous diseases. Apical membrane …

SpyStapler-mediated assembly of nanoparticle vaccines

S Kou, W Chen, C Sun, F Sun - Nano Research, 2023 - Springer
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has wreaked havoc around the globe, with no end in sight. The rapid …

Protective Immunity Induced by Immunization with Baculovirus, Virus-like Particle, and Vaccinia Virus Expressing the AMA1 of Plasmodium berghei

MJ Kim, KB Chu, HJ Kang, KW Yoon, GD Eom, J Mao… - Biomedicines, 2022 - mdpi.com
Heterologous prime–boost immunization regimens using various vaccine platforms
demonstrated promising results against infectious diseases. Here, mice were sequentially …

Protection and Alleviated Inflammation Induced by Virus-like Particle Vaccines Containing Plasmodium berghei MSP-8, MSP-9 and RAP1

SH Lee, KB Chu, HJ Kang, FS Quan - Vaccines, 2022 - mdpi.com
Virus-like particles (VLP) are a highly efficient vaccine platform used to present multiple
antigenic proteins. Merozoite surface protein 8 (MSP-8), 9 (MSP-9) and rhoptry-associated …

Influenza virus-like particle vaccine containing both apical membrane antigen 1 and microneme-associated antigen proteins of Plasmodium berghei confers …

MJ Kim, KB Chu, HJ Kang, KW Yoon, DH Lee, SH Lee… - BMC immunology, 2022 - Springer
Background Apical membrane antigen 1 (AMA1) and microneme-associated antigen (MIC)
of Plasmodium parasites are important factors involved in host cell invasion. Methods In this …

[HTML][HTML] Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane …

MJ Kim, KB Chu, KW Yoon, HJ Kang… - Parasites, Hosts and …, 2024 - ncbi.nlm.nih.gov
Malaria is a global disease affecting a large portion of the world's population. Although
vaccines have recently become available, their efficacies are suboptimal. We generated …