Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …

As one of the most abundant immune cell populations in the tumor microenvironment (TME),
tumor‐associated macrophages (TAMs) play important roles in multiple solid malignancies …

Macrophages (Mϕ) are prominent components of solid tumors and exhibit distinct
phenotypes in different microenvironments. We have recently found that tumors can alter the …

Since the discovery of the “nude” mouse more than 40 years ago, investigators have
attempted to model human tumor growth in immunodeficient mice. Here, we summarize how …

Traditional anticancer chemotherapeutics targeting DNA replication and cell division have
severe side effects, but they have proved to be highly successful in treating some cancers …

Background Ovarian cancer causes more than 15000 deaths per year in the United States.
The survival of patients is quite heterogeneous, and accurate prognostic tools would help …

Objective: To analyze the efficacy of engineered mesenchymal stem cell based therapy
directed towards pancreatic tumor stroma. Summary Background Data: Mesenchymal stem …

Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and
immune cells within the tumor microenvironment. Endothelial cells (ECs) are also ubiquitous …

The proinflammatory IL-17–producing CD8+ T cells (Tc17 cells) have recently been
detected in tumors, but the nature and regulation of these cells in human tumors are …

This study evaluated a biodegradable drug delivery system for local cancer radiotherapy
consisting of a thermally sensitive elastin-like polypeptide (ELP) conjugated to a therapeutic …