Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Confining molecules can fundamentally change their chemical and physical properties.
Confinement effects are considered instrumental at various stages of the origins of life, and …

A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

Microorganisms have provided abundant sources of natural products which have been
developed as commercial products for human medicine, animal health, and plant crop …

Enzymatic reactions in living cells are highly dynamic but simultaneously tightly regulated.
Enzyme engineers seek to construct multienzyme complexes to prevent intermediate …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Modular polyketide synthases (PKSs) run catalytic reactions over dozens of steps in a highly
orchestrated manner. To accomplish this synthetic feat, they form megadalton multienzyme …

Covering: up to mid of 2018 Type I fatty acid synthases (FASs) are giant multienzymes
catalyzing all steps of the biosynthesis of fatty acids from acetyl-and malonyl-CoA by iterative …

Many important natural products are produced by multidomain non-ribosomal peptide
synthetases (NRPSs),,,. During synthesis, intermediates are covalently bound to integrated …

Assembly-line polyketide synthases, such as the 6-deoxyerythronolide B synthase (DEBS),
are large enzyme factories prized for their ability to produce specific and complex polyketide …