Epigenetics as a mediator of plasticity in cancer
AP Feinberg, A Levchenko - Science, 2023 - science.org
The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
Applications of single-cell sequencing in cancer research: progress and perspectives
Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia
The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …
therapies entering clinical translation, yet patient responses remain heterogeneous, and …
Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML
Background Cancer patients can achieve dramatic responses to chemotherapy yet retain
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …
Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia
Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
Research progress of TXNIP as a tumor suppressor gene participating in the metabolic reprogramming and oxidative stress of cancer cells in various cancers
Y Chen, J Ning, W Cao, S Wang, T Du, J Jiang… - Frontiers in …, 2020 - frontiersin.org
Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate
oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of …
oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of …
Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment
R Guo, M Lü, F Cao, G Wu, F Gao, H Pang, Y Li… - Biomarker …, 2021 - Springer
Background Knowledge of immune cell phenotypes, function, and developmental trajectory
in acute myeloid leukemia (AML) microenvironment is essential for understanding …
in acute myeloid leukemia (AML) microenvironment is essential for understanding …
Improving bulk RNA-seq classification by transferring gene signature from single cells in acute myeloid leukemia
The advances in single-cell RNA sequencing (scRNA-seq) technologies enable the
characterization of transcriptomic profiles at the cellular level and demonstrate great promise …
characterization of transcriptomic profiles at the cellular level and demonstrate great promise …
Haploidentical stem cell transplantation for acute myeloid leukemia: current therapies, challenges and future prospective
YJ Chang, XY Zhao, XJ Huang - Frontiers in Oncology, 2021 - frontiersin.org
Haploidentical stem cell transplantation (haplo-SCT), an alternative donor source, offers a
curative therapy for patients with acute myeloid leukemia (AML) who are transplant …
curative therapy for patients with acute myeloid leukemia (AML) who are transplant …