Recent advances in ruthenium-based olefin metathesis

OM Ogba, NC Warner, DJ O'leary… - Chemical Society …, 2018 - pubs.rsc.org
Ruthenium-based olefin metathesis catalysts, known for their functional group tolerance and
broad applicability in organic synthesis and polymer science, continue to evolve as an …

C− H activation for the construction of C− B bonds

IAI Mkhalid, JH Barnard, TB Marder, JM Murphy… - Chemical …, 2010 - ACS Publications
A long-standing challenge in synthetic chemistry is the direct, selective functionalization of
alkyl, alkenyl, and aryl CH bonds. Much research has been devoted to the selective …

Analysis of past and present synthetic methodologies on medicinal chemistry: where have all the new reactions gone? Miniperspective

DG Brown, J Bostrom - Journal of medicinal chemistry, 2016 - ACS Publications
An analysis of chemical reactions used in current medicinal chemistry (2014), three decades
ago (1984), and in natural product total synthesis has been conducted. The analysis …

The Development of L2X2RuCHR Olefin Metathesis Catalysts:  An Organometallic Success Story

TM Trnka, RH Grubbs - Accounts of Chemical Research, 2001 - ACS Publications
In recent years, the olefin metathesis reaction has attracted widespread attention as a
versatile carbon− carbon bond-forming method. Many new applications have become …

A general model for selectivity in olefin cross metathesis

AK Chatterjee, TL Choi, DP Sanders… - Journal of the American …, 2003 - ACS Publications
In recent years, olefin cross metathesis (CM) has emerged as a powerful and convenient
synthetic technique in organic chemistry; however, as a general synthetic method, CM has …

Olefin metathesis and beyond

A Fürstner - Angewandte Chemie International Edition, 2000 - Wiley Online Library
The advent of well‐defined catalysts for olefin metathesis which combine high activity,
durability, and excellent tolerance towards polar functional groups has revolutionized the …

Olefin metathesis

RH Grubbs - Tetrahedron, 2004 - Elsevier
Olefin metathesis has become a tool for synthetic organic and polymer chemists. Well-
defined, functional group tolerant catalysts have allowed these advances. A discussion of …

Enol ethers are effective monomers for ring-opening metathesis polymerization: synthesis of degradable and depolymerizable poly (2, 3-dihydrofuran)

JD Feist, Y Xia - Journal of the American Chemical Society, 2019 - ACS Publications
Enol ethers are widely used as quenching reagents for Grubbs catalysts. However, we
report the surprisingly effective ring-opening metathesis polymerization (ROMP) of cyclic …

Metathesis reactions in total synthesis

KC Nicolaou, PG Bulger… - Angewandte Chemie …, 2005 - Wiley Online Library
With the exception of palladium‐catalyzed cross‐couplings, no other group of reactions has
had such a profound impact on the formation of carbon–carbon bonds and the art of total …

Enyne metathesis (enyne bond reorganization)

ST Diver, AJ Giessert - Chemical reviews, 2004 - ACS Publications
Enyne metathesis is a bond reorganization of an alkene and an alkyne to produce a 1, 3-
diene (eqs 1 and 2 in Scheme 1). It has been used in both intramolecular and intermolecular …