The halogen bond occurs when there is evidence of a net attractive interaction between an
electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic …

Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …

The concept of functional groups (FGs), sets of connected atoms that can determine the
intrinsic reactivity of the parent molecule and in part are responsible for the overall …

The electrophilic halogenation of arenes is perhaps the simplest method to prepare aryl
halides, which are important structural motifs in agrochemicals, materials, and …

Supramolecular chemistry is “the chemistry of the intermolecular bond, covering the
structures and functions of the entities formed by association of two or more chemical …

The design of stimuli-responsive systems in nanomedicine arises from the challenges
associated with the unsolved needs of current molecular drug delivery. Here, we present a …

As the protein databank (PDB) recently passed the cap of 123 456 structures, it stands more
than ever as an important resource not only to analyze structural features of specific …

The high utility of halogenated organic compounds has prompted the development of a vast
number of transformations which install the carbon–halogen motif. Traditional routes to …

In the field of noncovalent interactions a new paradigm has recently become popular. It
stems from the analysis of molecular electrostatic potentials and introduces a label, which …

This review describes the recent Food and Drug Administration (FDA)-approved drugs (in
the year 2021) containing at least one halogen atom (covalently bound). The structures …