The Keap1‐Nrf2 system: a mediator between oxidative stress and aging

C Yu, JH Xiao - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

[HTML][HTML] Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

Y Gao, Y Chi, Y Chen, W Wang, H Li, W Zheng… - Nature …, 2023 - nature.com
Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been
extensively investigated for their therapeutic potential in treating inflammatory disorders …

Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells

A Qadir, S Liang, Z Wu, Z Chen, L Hu… - International journal of …, 2020 - mdpi.com
Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

[HTML][HTML] Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

A Borodkina, A Shatrova, P Abushik, N Nikolsky… - Aging (Albany …, 2014 - ncbi.nlm.nih.gov
Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature
senescence under sublethal oxidative stress, however underlying mechanism remains …

The role of mesenchymal stem cells in radiation-induced lung fibrosis

M Zanoni, M Cortesi, A Zamagni, A Tesei - International journal of …, 2019 - mdpi.com
Radiation therapy is one of the most important treatment modalities for thoracic tumors.
Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still …

[HTML][HTML] Anti-oxidant potential of plants and probiotic spp. in alleviating oxidative stress induced by H2O2

H Kumar, R Dhalaria, S Guleria, R Cimler… - Biomedicine & …, 2023 - Elsevier
Cells produce reactive oxygen species (ROS) as a metabolic by-product. ROS molecules
trigger oxidative stress as a feedback response that significantly initiates biological …

Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium

E Burova, A Borodkina, A Shatrova… - … medicine and cellular …, 2013 - Wiley Online Library
The specific responses of mesenchymal stem cells to oxidative stress may play a crucial role
in regulation of tissue homeostasis as well as regeneration of organs after oxidative injury …

[HTML][HTML] Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process

N Alessio, S Del Gaudio, S Capasso, G Di Bernardo… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Low doses of radiation may have profound effects on cellular function. Individuals may be
exposed to low doses of radiation either intentionally for medical purposes or accidentally …

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

YQ Geng, JT Guan, XH Xu, YC Fu - Biochemical and biophysical research …, 2010 - Elsevier
To investigate the activity of senescence-associated beta-galactosidase (SA-beta-GAL) in
the hippocampus of aging rats. Hippocampi of 6-, 18-, and 24-month-old rats were observed …