Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

Photoreceptor cell death is the ultimate cause of vision loss in various retinal disorders,
including retinal detachment (RD). Photoreceptor cell death has been thought to occur …

The precise regulation of programmed cell death is critical for the normal development of the
nervous system. We show here that DYRK1A (minibrain), a protein kinase essential for …

Retinal degeneration, including that seen in age-related macular degeneration and retinitis
pigmentosa (RP), is the most common form of neural degenerative disease in the world …

Mutations in humans are associated with several forms of inherited retinal dystrophies, such
as Retinitis Pigmentosa which lead to retinal cell death and irreversible loss of vision. Genes …

Using retinal organoid systems, organ-like 3D tissues, relies implicitly on their robustness.
However, essential key parameters, particularly retinal growth and longer-term culture, are …

During retinal neurogenesis, diverse cellular subtypes originate from multipotent neural
progenitors in a spatiotemporal order leading to a highly specialized laminar structure …

Axonal insult induces retinal ganglion cell (RGC) death through a BAX-dependent process.
The pro-apoptotic Bcl-2 family member BIM is known to induce BAX activation. BIM …

Background It has been recognized that cells do not respond equally to ultraviolet (UV)
radiation but it is not clear whether this is due to genetic, biochemical or structural …