AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

In contrast to wet age-related macular degeneration (AMD), where loss of vision is typically
acute and treatment leads to a relatively rapid reduction in retinal fluid and subsequent …

Age-related diseases, including age-related macular degeneration (AMD), are of growing
importance in a world where population ageing has become a dominant global trend …

Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical
practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the …

Purpose To examine whether slowed rod-mediated dark adaptation (DA) in adults with
normal macular health at baseline is associated with the incidence of age-related macular …

Purpose.: Lipofuscin (LF) accumulation within RPE cells is considered pathogenic in AMD.
To test whether LF contributes to RPE cell loss in aging and to provide a cellular basis for …

Recent developments in imaging technologies now allow the documentation, qualitative and
quantitative evaluation of peripheral retinal lesions. As wide field retinal imaging, capturing …

Commercially available white light‐emitting diodes (LEDs) have an intense emission in the
range of blue light, which has raised a range of public concerns about their potential risks as …

Purpose To determine whether emixustat hydrochloride (emixustat) reduces the rate of
enlargement of geographic atrophy (GA) compared with placebo in subjects with age …

Lipids can undergo modification as a result of interaction with reactive oxygen species
(ROS). For example, lipid peroxidation results in the production of a wide variety of highly …