Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still developing based on the …

In medicinal chemistry, 2-aminothiophene is a central five-membered heterocyclic core that
is mostly synthesized using Gewald methodology. Its incorporation into a molecule can …

Background Naturally occurring flavonoids have been reported to possess various
pharmacological properties. The aim of this study was to evaluate the antimicrobial and …

Synthesis of nitriles, esters, amides of the substituted 2-amino-1-(4, 5, 6, 7-tetra-hydrobenzo
[b] thiophen-2-yl)-4-oxo-5-(2-oxo-2-arylethylidene)-4, 5-dihydro-1 H-pyrrole-3-carboxylic …

A highly enantioselective copper‐catalyzed vinylogous propargylic substitution has been
developed. Aromatic and aliphatic propargylic esters react smoothly with substituted …

A straightforward access to 2‐amino‐3‐arylthiophenes has been developed via one‐pot two‐
step three‐component reaction of arylacetonitriles, chalcones and elemental sulfur. The first …

Herein, we report a one‐pot viable protocol to synthesize tetrasubstituted 2‐
aminothiophenes engaging readily accessible α‐enolic dithioesters and abundant …

Aryl-4-oxo-2-(thiophen-2-ylamino) but-2-enoates bearing a cyano functional group at the
thiophene ring were synthesized by the reaction of the corresponding substituted 3 …

The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is
presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this …

While the utility of vinylogous enolates is well established in the setting of vinylogous aldol,
Mannich, and Michael chemistries, literature reports concerning γ‐reactivity are scarce for …