NRF2, a transcription factor for stress response and beyond

F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Immunometabolism: from basic mechanisms to translation

L Makowski, M Chaib, JC Rathmell - Immunological reviews, 2020 - Wiley Online Library
Immunometabolism has emerged as a major mechanism central to adaptive and innate
immune regulation. From early observations that inflammatory cytokines were induced in …

NRF2 as a regulator of cell metabolism and inflammation in cancer

F He, L Antonucci, M Karin - Carcinogenesis, 2020 - academic.oup.com
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …

[HTML][HTML] Beyond repression of Nrf2: An update on Keap1

A Kopacz, D Kloska, HJ Forman, A Jozkowicz… - Free Radical Biology …, 2020 - Elsevier
Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

[HTML][HTML] AMPK and NRF2: Interactive players in the same team for cellular homeostasis?

E Petsouki, SNS Cabrera, EH Heiss - Free Radical Biology and Medicine, 2022 - Elsevier
NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Redox signaling at the crossroads of human health and disease

J Zuo, Z Zhang, M Luo, L Zhou, EC Nice, W Zhang… - MedComm, 2022 - Wiley Online Library
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Dendrobium officinale polysaccharide triggers mitochondrial disorder to induce colon cancer cell death via ROS-AMPK-autophagy pathway

K Zhang, X Zhou, J Wang, Y Zhou, W Qi, H Chen… - Carbohydrate …, 2021 - Elsevier
The homeostasis between mitochondrial function and autophagy is crucial to the
physiological activity of cancer cells, and its mechanism is conducive to the development of …

The immunometabolic ecosystem in cancer

GR Bantug, C Hess - Nature Immunology, 2023 - nature.com
Our increased understanding of how key metabolic pathways are activated and regulated in
malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to …

[HTML][HTML] Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes

C Moschandrea, V Kondylis, I Evangelakos, M Herholz… - Nature, 2024 - nature.com
Digested dietary fats are taken up by enterocytes where they are assembled into pre-
chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation …

Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage

MR Boothby, SK Brookens, AL Raybuck… - Cellular & Molecular …, 2022 - nature.com
The COVID pandemic has refreshed and expanded recognition of the vital role that
sustained antibody (Ab) secretion plays in our immune defenses against microbes and of …