Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Abstract Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the
transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and …

Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Fusion-transcription factors (fusion-TFs) represent a class of driver oncoproteins that are
difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to …

Human innate immunity responds to viral infection by activating the production of interferons
(IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a …

The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in
various biological processes, especially in regulating a wide range of signaling pathways …

The increasing prevalence of antibacterial resistance globally underscores the urgent need
to the update of antibiotics. Here, we describe a strategy for inducing the self-assembly of a …

TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein
required for innate immune responses mediated by Toll-like receptor (TLR) 3-and TLR4 …

Background Acute kidney injury (AKI) emerges as an acute and critical disease. Tripartite
motif 8 (TRIM8), one number of the TRIM protein family, is proved to participate in …