Prebiotic peptides: Molecular hubs in the origin of life
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
Interactions by disorder–a matter of context
K Bugge, I Brakti, CB Fernandes, JE Dreier… - Frontiers in Molecular …, 2020 - frontiersin.org
Living organisms depend on timely and organized interactions between proteins linked in
interactomes of high complexity. The recent increased precision by which protein …
interactomes of high complexity. The recent increased precision by which protein …
From interaction networks to interfaces, scanning intrinsically disordered regions using AlphaFold2
The revolution brought about by AlphaFold2 opens promising perspectives to unravel the
complexity of protein-protein interaction networks. The analysis of interaction networks …
complexity of protein-protein interaction networks. The analysis of interaction networks …
[HTML][HTML] Target 2035: probing the human proteome
AJ Carter, O Kraemer, M Zwick, A Mueller-Fahrnow… - Drug Discovery …, 2019 - Elsevier
Highlights•Natural tendency for researchers to focus on a small fraction of the human
proteome.•Pharmacological modulators are one of the best ways of interrogating the …
proteome.•Pharmacological modulators are one of the best ways of interrogating the …
TransformerGO: predicting protein–protein interactions by modelling the attention between sets of gene ontology terms
Abstract Motivation Protein–protein interactions (PPIs) play a key role in diverse biological
processes but only a small subset of the interactions has been experimentally identified …
processes but only a small subset of the interactions has been experimentally identified …
Network biology discovers pathogen contact points in host protein-protein interactomes
In all organisms, major biological processes are controlled by complex protein–protein
interactions networks (interactomes), yet their structural complexity presents major analytical …
interactions networks (interactomes), yet their structural complexity presents major analytical …
BIPSPI: a method for the prediction of partner-specific protein–protein interfaces
Abstract Motivation Protein–Protein Interactions (PPI) are essentials for most cellular
processes and thus, unveiling how proteins interact is a crucial question that can be better …
processes and thus, unveiling how proteins interact is a crucial question that can be better …
Mapping, structure and modulation of PPI
Because of the key relevance of protein–protein interactions (PPI) in diseases, the
modulation of protein-protein complexes is of relevant clinical significance. The successful …
modulation of protein-protein complexes is of relevant clinical significance. The successful …
CETSA in integrated proteomics studies of cellular processes
Abstract The Cellular Thermal Shift Assay (CETSA) has recently emerged as a promising
method to directly monitor functional modulations of protein interaction states in intact cells …
method to directly monitor functional modulations of protein interaction states in intact cells …
Are transient protein-protein interactions more dispensable?
Protein-protein interactions (PPIs) are key drivers of cell function and evolution. While it is
widely assumed that most permanent PPIs are important for cellular function, it remains …
widely assumed that most permanent PPIs are important for cellular function, it remains …