Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Background Over the last three decades, consumption of total and saturated fat has steadily
declined in Western diets as a proportion of calories intake. At the same time, omega (ω)-6 …

Diverse health benefits are associated with dietary consumption of omega-3 long-chain
polyunsaturated fatty acids (ω-3 LC-PUFA), particularly docosahexaenoic acid (DHA) and …

A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on
their brain health and behavior. During the past three decades, obesity has rapidly …

Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …

Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

Pediatric obesity is a progressive, chronic disease that can lead to serious cardiometabolic
complications. Here we investigated the peripheral lipidome in 958 children and …