Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

The redefinition of neuropathic pain, 23 which specifically excludes the concept of
“dysfunction,” has left a large group of patients without a valid pathophysiological descriptor …

Central sensitization (CS), simply defined as an amplified response of the central nervous
system to peripheral input, is a concept of great importance in clinical medicine. It has …

Introduction: Central sensitization (CS) is present in a variety of chronic pain disorders,
including whiplash, temporomandibular disorders, low back pain, osteoarthritis …

Introduction Hyperexcitability of the central nervous system has been suggested to play an
important role in pain experienced by patients with unilateral shoulder pain. A systematic …

Osteoarthritis (OA) is a global disease that, despite extensive research, has limited treatment
options. Pet dogs share both an environment and lifestyle attributes with their owners, and a …

1. Background Osteoarthritis is a leading cause of chronic pain, and when painful
osteoarthritis cannot be managed in primary care, joint replacement surgery is often …

Trigger points (TrP) are hyperirritable spots in a taut band of a skeletal muscle, which usually
have referred pain. There is controversy over whether TrP are a peripheral or central …

Purpose To evaluate the structure-modifying and symptom efficacy, as well as safety and
tolerability of oral salmon calcitonin (sCT) formulated with a 5-CNAC carrier (a molecule …

Background Central sensitization plays an important role in the chronic pain experienced by
osteoarthritis (OA) patients. In this prospective observational study, we investigated the …